Торговое название:
- Биватрацин
- Bivatracin
Состав:
Каждые 150 мл спрея содержат:
- Неомицина сульфат – 165 000 М.Е.
- Бацитрацин цинка – 12 500 М.Е.
- Гидрокарбоновый аэрозоль до – 150 мл
Свойства:
- Бацитрацин является полипептидным антибиотиком, который ингибирует синтез клеточной оболочки бактерий. Бацитрацин особенно активен в отношении грамположительных микроорганизмов, таких как β-гемолитические стрептококки, стафилококки, и некоторых грамотрицательных патогенов. Резистентность к бацитрацину встречается чрезвычайно редко.
- Неомицин является антибиотиком-аминогликозидом, который ингибирует синтез белков бактерий. Активен в отношении грамположительных и грамотрицательных бактерий.
- Благодаря использованию комбинации этих двух антибиотиков достигается широкий спектр действия данного средства и синергизм действия в отношении ряда микроорганизмов, например, стафилококков.
Показания:
Применяется для лечения и профилактики инфекций, вызванных микроорганизмами, чувствительными к неомицину и/или бацитрацину: бактериальные инфекции кожи ограниченной распространенности.
Способ применения и дозы:
Наружно. Хорошо взболтать перед нанесением. Аэрозоль распылять тонким слоем на расстоянии 20-25 см на пораженные участки 2 – 4 раза в день взрослым и детям; если это целесообразно – под повязку. Площадь нанесения порошка не должна превышать 1 % от площади поверхности тела (что соответствует размеру ладони пациента).
При местном применении доза неомицина для взрослых и детей до 18 лет не должна превышать 1 г/сут (около 200 г порошка для наружного применения) в течение 7 дней.Пациентам с нарушением функции печени/почек, пожилого возраста коррекция дозы не требуется.
Противопоказания:
- Повышенная чувствительность к бацитрацину, неомицину, антибиотикам аминогликозидного ряда, вспомогательным веществам препарата;
- Инфекции наружного слухового прохода с перфорацией барабанной перепонки;
- Применение порошка для лечения инфекций глаз.
Меры предосторожности:
При длительном лечении должно уделяться внимание возможному росту устойчивых микроорганизмов. В таких ситуациях следует выбрать соответствующую тактику лечения.В случае применения препарата у детей, пациентов с нарушенной функцией печени и почек, а также при большой площади обрабатываемой поверхности, длительном применении и глубоких поражениях кожи рекомендуется предварительно проконсультироваться с врачом. Пациентам, у которых развилась аллергия или суперинфекция, препарат должен быть отменен.
Побочные эффекты:
- Препарат обычно хорошо переносится при наружном применении.
- Со стороны кожи и подкожных тканей: редко — аллергические реакции, манифестирующие в виде контактного дерматита, аллергическая реакция на неомицин; частота неизвестна — аллергические реакции в виде покраснения и сухости кожи, кожных высыпаний и зуда (при длительном применении).
- Со стороны почек и мочевыводящих путей: частота неизвестна — нефротоксичность.
Способ хранения:
При температуре не выше 25 градусов.
Упаковка:
Картонная коробка вмещает алюминиевый баллон 150 мл.
Торговое название:
Биватрацин
Bivatracin
Состав:
Каждые 150 мл спрея содержат:
Неомицина сульфат 165 000 М.Е.
Бацитрацин цинка 12 500 М.Е.
Гидрокарбоновый аэрозоль до 150 мл
Свойства:
Бацитрацин является полипептидным антибиотиком, который ингибирует синтез клеточной оболочки бактерий. Бацитрацин особенно активен в отношении грамположительных микроорганизмов, таких как β-гемолитические стрептококки, стафилококки, и некоторых грамотрицательных патогенов. Резистентность к бацитрацину встречается чрезвычайно редко.
Неомицин является антибиотиком-аминогликозидом, который ингибирует синтез белков бактерий. Активен в отношении грамположительных и грамотрицательных бактерий.
Благодаря использованию комбинации этих двух антибиотиков достигается широкий спектр действия данного средства и синергизм действия в отношении ряда микроорганизмов, например, стафилококков.
Показания:
Применяется для лечения и профилактики инфекций, вызванных микроорганизмами, чувствительными к неомицину и/или бацитрацину: бактериальные инфекции кожи ограниченной распространенности.
Способ применения и дозы:
Наружно. Хорошо взболтать перед нанесением. Аэрозоль распылять тонким слоем на расстоянии 20-25см на пораженные участки 2 – 4 раза в день взрослым и детям; если это целесообразно – под повязку. Площадь нанесения порошка не должна превышать 1 % от площади поверхности тела (что соответствует размеру ладони пациента).
При местном применении доза неомицина для взрослых и детей до 18 лет не должна превышать 1 г/сут (около 200 г порошка для наружного применения) в течение 7 дней.
Пациентам с нарушением функции печени/почек, пожилого возраста коррекция дозы не требуется.
Противопоказания:
повышенная чувствительность к бацитрацину, неомицину, антибиотикам аминогликозидного ряда, вспомогательным веществам препарата;
-инфекции наружного слухового прохода с перфорацией барабанной перепонки;
-применение порошка для лечения инфекций глаз.
Меры предосторожности:
При длительном лечении должно уделяться внимание возможному росту устойчивых микроорганизмов. В таких ситуациях следует выбрать соответствующую тактику лечения.
В случае применения препарата у детей, пациентов с нарушенной функцией печени и почек, а также при большой площади обрабатываемой поверхности, длительном применении и глубоких поражениях кожи рекомендуется предварительно проконсультироваться с врачом. Пациентам, у которых развилась аллергия или суперинфекция, препарат должен быть отменен.
Побочные эффекты:
Препарат обычно хорошо переносится при наружном применении.
Со стороны кожи и подкожных тканей: редко — аллергические реакции, манифестирующие в виде контактного дерматита, аллергическая реакция на неомицин; частота неизвестна — аллергические реакции в виде покраснения и сухости кожи, кожных высыпаний и зуда (при длительном применении).
Со стороны почек и мочевыводящих путей: частота неизвестна — нефротоксичность.
Способ хранения:
При температуре не выше 25 градусов.
Упаковка:
Картонная коробка вмещает алюминиевый баллон 150 мл.
Bivatracin Topical
Bacitracin is a combination of at least 9 bacitracins. 60-80% of commercially prepared bacitracin is bacitracin A. The bacillus that produces bacitracin was first isolated from a knee scrape in 1945 from the knee wound of a child named Margaret Tracy.
Bacitracin was granted FDA approval on 29 July 1948.
Bacitracin is a mixture of polypeptides that prevent the formation of the bacterial cell wall and oxidatively cleave DNA. It has a short duration of action as it must be given every 3 to 4 hours topically. Bacitracin is nephrotoxic when given intramuscularly and may lead to renal failure.
Neomycin is a broad-spectrum aminoglycoside antibiotic drug that is derived from the metabolic products of Streptomyces fradiae. Neomycin is a complex comprised of three components, neomycin A, B, and C. Neomycin B, also known as framycetin, is the most active component of the complex and neomycin C is the isomer of neomycin B, making these two stereoisomers the active components of neomycin. Neomycin A, or neamine, is a moiety that conjoins two molecules of neomycin B and C together. Neomycin is active against both gram-positive and gram-negative organisms and mediates its pharmacological action by binding to bacterial ribosomes and inhibiting protein synthesis, which is crucial for the survival of bacteria.
Neomycin sulfate is the most common form for pharmaceutical preparations; because the compound is a complex, the amount of neomycin in products is measured in units. Neomycin sulfate as monotherapy is available in an oral solution for adjunct use in the treatment of hepatic coma. It is also used in combination with polymyxin B sulfates and hydrocortisone in otic suspensions for use in the treatment of bacterial infections in the external auditory canal, including infections caused by medical procedures in the ear. Neomycin is also used in combination with polymyxin B sulfates and dexamethasone in ophthalmic preparations for use in the treatment of inflammatory conditions and infections in the eye. Neomycin is also available in over-the-counter topical products to prevent minor skin infections.
Neomycin mediates its bactericidal action by inhibiting bacterial protein synthesis, thereby suppressing the growth and survival of susceptible bacteria. Following oral administration, the duration of bactericidal activity of neomycin ranged from 48 to 72 hours. By decreasing colonic bacteria that produce ammonia, neomycin was shown to be effective as an adjunctive therapy in hepatic coma to improve neurologic symptoms.
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Uses
Bacitracin is a cyclic polypeptide antibiotic used to prevent wound infections, treat pneumonia and empyema in infants, and to treat skin and eye infections.
Bacitracin is indicated in topical formulations for acute and chronic localized skin infections. Occasionally, it is also used intramuscularly for infantile streptococcal pneumonia and empyema. Bacitracin is also formulated as an ointment with neomycin and polymyxin B for over the counter use. A bacitracin ointment formulated with neomycin and polymyxin B along with hydrocortisone is indicated for the treatment of corticosteroid responsive dermatoses with secondary infection.
Neomycin is an aminoglycoside antibiotic agent used orally and topically to treat a wide variety of infections in the body.
Oral neomycin sulfate is indicated as an adjunctive therapy in hepatic coma (portal-system encephalopathy) by reducing ammonia-forming bacteria in the intestinal tract. It is strongly recommended that oral neomycin is only used in infections that are proven or strongly suspected to be caused by susceptible bacteria to reduce the risk of the development of drug-resistant bacteria.
Neomycin, in combination with polymyxin B sulfates and hydrocortisone in otic suspensions, is used in the treatment of superficial bacterial infections of the external auditory canal caused by organisms susceptible to the antibiotics. This otic formulation is also used in the treatment of infections of mastoidectomy and fenestration cavities caused by organisms susceptible to the antibiotics.
The ophthalmic solution containing neomycin in combination with polymyxin B sulfates and dexamethasone is used to treat steroid-responsive inflammatory ocular conditions for which a corticosteroid is indicated and where bacterial infection or a risk of bacterial infection exists.
Bivatracin Topical is also used to associated treatment for these conditions: Acne, Bacterial Infections of the Intestine, Empyema, Eye Infections, Infected Wound, Infection, Inflammatory Reaction caused by Acne, Ocular Inflammatory Disease, Pneumonia, Skin Ulcer, Corticosteroid-responsive dermatoses, Infection in minor cuts, scrapes, or burns, Wound siteAcne pustular, Allergic Contact Dermatitis, Allergy Skin, Atopic Dermatitis (AD), Atopic Dermatitis (AD) of the external ear canal, Bacterial diarrhoea, Burns, Carbuncle, Cradle Cap, Dermatitis, Dermatitis, Contact, Dermatitis, Eczematous, Diarrhoea, Discoid Lupus Erythematosus (DLE), Ear infection bacterial, Ear infection bacterial caused by susceptible bacteria, Gastrointestinal Infections, Hepatic coma, Hidradenitis Suppurativa (HS), Hot Water Burns (Scalds), Impetigo, Impetigo contagious, Infantile Eczema, Infected Wounds, Infected skin ulcer, Infection of the outer ear caused by susceptible bacteria, Infectious diarrhea, Inflammatory Reaction caused by Acne, Intertrigo, Itching caused by Infection, Lichen Planus (LP), Localized Infection caused by susceptible bacteria, Nail infection, Neurodermatitis, Otitis Externa, Postoperative Wound Infection, Psoriasis Vulgaris (Plaque Psoriasis), Pustular Dermatosis, Radiodermatitis, Secondarily Infected Eczema, Secondary Bacterial Infection, Skin Burns, Skin Infections, Skin Infections, Bacterial, Skin Irritation, Skin Ulcer, Solar erythema, Abrasions, Blistering caused by Staphylococcus, Erythematous eruptions, Intertriginous erythema of the anogenital, Ocular bacterial infections caused by susceptible bacteria, Resistant to other corticosteroids Dermatosis, Susceptible Bacterial Infections
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How Bivatracin Topical works
Bacitracin binds to a divalent metal ion such as Mn(II), Co(II), Ni(II), Cu(II), or Zn(II). These complexes bind C55-isoprenyl pyrophosphate, preventing the hydrolysis of a lipid dolichol pyrophosphate, which finally inhibits cell wall synthesis. Bacitracin metal complexes also bind and oxidatively cleave DNA.
Like other aminoglycoside antibiotic drugs, neomycin inhibits bacterial ribosomes by binding to the 30S ribosomal subunit of susceptible bacteria and disrupting the translational machinery of bacterial protein synthesis. Bacterial translation is normally initiated by the mRNA binding to the 30S ribosomal subunit and subsequent binding with 50S subunit for elongation.
Structure
Table Of contents
- Bivatracin Topical
- Uses
- Dosage
- Side Effect
- Precautions
- Interactions
- Uses during Pregnancy
- Uses during Breastfeeding
- Accute Overdose
- Food Interaction
- Half Life
- Volume of Distribution
- Clearance
- Interaction With other Medicine
- Contradiction
- Storage
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Toxicity
The oral LD50 of bacitracin in rats is >2000mg/kg.
Specific data regarding bacitracin overdoses is not readily available. An overdose of bacitracin may lead to nephrotoxicity and patients should be treated with supportive measures.
The oral LD50 of neomycin sulfate in mouse is > 8 g/kg. The subcutaneous LD50 is 200 mg/kg in rat and 190 mg/kg in mouse. The intraperitoneal LD50 in mouse is 305 mg/kg. The oral Lowest published toxic dose (TDLo) in woman is 12600 mg/kg/7D.
Because of low absorption, acute overdosage from oral neomycin is not likely to occur. However, prolonged administration of neomycin should be avoided because of the possibility of some systemic absorption and the risk of neurotoxicity, ototoxicity, and/or nephrotoxicity. Hemodialysis will remove neomycin from the blood. While nephrotoxicity and ototoxicity have been reported in otherwise patients without compromised renal function, the risk for developing these toxicities is increased in patients with renal impairment. Like other aminoglycosides, neomycin may cause fetal harm and total irreversible bilateral congenital deafness when administered in pregnant women.
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Volume of Distribution
Data regarding the volume of distribution of bacitracin in humans is not readily available.
The small fraction of absorbed neomycin is rapidly distributed in the tissues. The amount of systemically absorbed neomycin is reported to increase cumulatively with each repeated dose administered until a steady state is reached.
Elimination Route
Topical, ophthalmic, and oral formulations of bacitracin are poorly absorbed systemically. Intramuscular bacitracin is readily and completely absorbed.
Neomycin is poorly absorbed from the gastrointestinal tract. Gastrointestinal absorption of the drug may be increased if inflammatory or ulcerative gastrointestinal disease is present.
Half Life
Data regarding the half life of bacitracin in humans is not readily available.
There is limited information on the half-life of neomycin.
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Clearance
Data regarding the clearance of bacitracin in humans has not been well studied. A study of 9 subjects in 1947 shows a renal clearance of 105-283mL/min with an average renal clearance of 159mL/min.
There is limited information on the clearance rate of neomycin.
Elimination Route
Bacitracin is mainly excreted renally with 87% of and intramuscular dose being recovered in the urine after 6 hours.
The small absorbed fraction of neomycin is excreted by the kidney. The unabsorbed portion of the drug is excreted unchanged in the feces.
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- Overview
- Uses
- Side-effects
- Precautions
- Interactions
- Contraindications
Overview
Bivatracin aerosol contains Bacitracin and Neomycin as active ingredients.
Bivatracin aerosol works by inhibiting the bacterial cell wall synthesis; preventing the bacterial growth by stopping the production of essential protein in the bacterial cells;
Detailed information related to Bivatracin aerosol’s uses, composition, dosage, side effects and reviews is listed below.
Uses
Side-effects
Precautions
Before using Bivatracin aerosol, inform your doctor about your current list of medications, over the counter products (e.g. vitamins, herbal supplements, etc.), allergies, pre-existing diseases, and current health conditions (e.g. pregnancy, upcoming surgery, etc.). Some health conditions may make you more susceptible to the side-effects of the drug. Take as directed by your doctor or follow the direction printed on the product insert. Dosage is based on your condition. Tell your doctor if your condition persists or worsens. Important counseling points are listed below.
- Caution is advised in patients suffering from parkinson’s disease
- Clean and dry the site of infection before applying medicine
- Confirm the route of administration with your doctor
- Cystic fibrosis
- Do not use for deep wounds, animal bites or severe burns
- Do not use for patients who are exposed to loud noise
- Ensure that you complete the duration of treatment
- External use only
- Infection with risk of becoming systemic
- Monitor neomycin levels in blood to prevent damage to ear and kidneys
Interactions with Bivatracin aerosol
If you use other drugs or over the counter products at the same time, the effects of Bivatracin aerosol may change. This may increase your risk for side-effects or cause your drug not to work properly. Tell your doctor about all the drugs, vitamins, and herbal supplements you are using, so that you doctor can help you prevent or manage drug interactions. Bivatracin aerosol may interact with the following drugs and products:
- Acarbose
- Aminoglycosides
- Amphotericin
- Ascorbic acid
- Atracurium
- Capreomycin
- Cephalosporins
- Ciprofloxacin
- Cyanocobalamin
- Cyclosporin
When not to use Bivatracin aerosol
Composition and Active Ingredients
Bivatracin aerosol is composed of the following active ingredients (salts)
- Bacitracin
- Neomycin
Please note that this medicine may be available in various strengths for each active ingredient listed above.
Packages and Strengths
Bivatracin aerosol is available in the following packages and strengths
Bivatracin aerosol — Packages: 150 gram
Frequently asked Questions
-
Is Bivatracin aerosol safe to use when pregnant?
- Bacitracin: Please consult with your doctor for case-specific recommendations.
- Neomycin: No
-
Is Bivatracin aerosol safe while breastfeeding?
- Bacitracin: Please discuss the risks and benefits with your doctor.
- Neomycin: No
-
Can Bivatracin aerosol be used for grazes and skin infections?
Yes, grazes and skin infections are among the most common reported uses for Bivatracin aerosol. Please do not use Bivatracin aerosol for grazes and skin infections without consulting first with your doctor. Click here and view survey results to find out what other patients report as common uses for Bivatracin aerosol.
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How long do I need to use Bivatracin aerosol before I see improvement of my conditions?
TabletWise.com website users have reported within 6 hours and 3 days as the most common time it takes before they saw improvements in their conditions. These times may not be reflective of what you may experience or how you should use this medicine. Please consult with your doctor to check how long do you need to use Bivatracin aerosol. Click here and view survey results to find out what other patients report as time for effectiveness for Bivatracin aerosol.
-
At what frequency do I need to use Bivatracin aerosol?
TabletWise.com website users have reported twice a day and once in 3 days as the most common frequency of using Bivatracin aerosol. Please follow your doctor’s advice on how often you need to Bivatracin aerosol. Click here and view survey results to find out what other patients report as frequency of using Bivatracin aerosol.
-
Should I use Bivatracin aerosol empty stomach, before food or after food?
TabletWise.com website users have most commonly reported using Bivatracin aerosol anytime. However, this may not be reflective of how you should use this medicine. Please follow your doctor’s advice on how you should use this medicine. Click here and view survey results to find out what other patients report as timing of using Bivatracin aerosol.
-
Is it safe to drive or operate heavy machinery when using this product?
If you experience drowsiness, dizziness, hypotension or a headache as side-effects when using Bivatracin aerosol medicine then it may not be safe to drive a vehicle or operate heavy machinery. One should not drive a vehicle if using the medicine makes you drowsy, dizzy or lowers your blood-pressure extensively. Pharmacists also advise patients not to drink alcohol with medicines as alcohol intensifies drowsiness side-effects. Please check for these effects on your body when using Bivatracin aerosol. Always consult with your doctor for recommendations specific to your body and health conditions.
-
Is this medicine or product addictive or habit forming?
Most medicines don’t come with a potential for addiction or abuse. Usually, the government’s categorizes medicines that can be addictive as controlled substances. Examples include schedule H or X in India and schedule II-V in the US. Please consult the product package to make sure that the medicine does not belong to such special categorizations of medicines. Lastly, do not self-medicate and increase your body’s dependence to medicines without the advice of a doctor.
-
Can i stop using this product immediately or do I have to slowly wean off the use?
Some medicines need to be tapered or cannot be stopped immediately because of rebound effects. Please consult with your doctor for recommendations specific to your body, health and other medications that you may be using.
Other important Information on Bivatracin aerosol
Missing a dose
In case you miss a dose, use it as soon as you notice. If it is close to the time of your next dose, skip the missed dose and resume your dosing schedule. Do not use extra dose to make up for a missed dose. If you are regularly missing doses, consider setting an alarm or asking a family member to remind you. Please consult your doctor to discuss changes in your dosing schedule or a new schedule to make up for missed doses, if you have missed too many doses recently.
Overdosage of Bivatracin aerosol
- Do not use more than prescribed dose. Taking more medication will not improve your symptoms; rather they may cause poisoning or serious side-effects. If you suspect that you or anyone else who may have overdosed of Bivatracin aerosol, please go to the emergency department of the closest hospital or nursing home. Bring a medicine box, container, or label with you to help doctors with necessary information.
- Do not give your medicines to other people even if you know that they have the same condition or it seems that they may have similar conditions. This may lead to overdosage.
- Please consult your physician or pharmacist or product package for more information.
Storage of Bivatracin aerosol
- Store medicines at room temperature, away from heat and direct light. Do not freeze medicines unless required by package insert. Keep medicines away from children and pets.
- Do not flush medications down the toilet or pour them into drainage unless instructed to do so. Medication discarded in this manner may contaminate the environment. Please consult your pharmacist or doctor for more details on how to safely discard Bivatracin aerosol.
Expired Bivatracin aerosol
- Taking a single dose of expired Bivatracin aerosol is unlikely to produce an adverse event. However, please discuss with your primary health provider or pharmacist for proper advice or if you feel unwell or sick. Expired drug may become ineffective in treating your prescribed conditions. To be on the safe side, it is important not to use expired drugs. If you have a chronic illness that requires taking medicine constantly such as heart condition, seizures, and life-threatening allergies, you are much safer keeping in touch with your primary health care provider so that you can have a fresh supply of unexpired medications.
Dosage Information
Please consult your physician or pharmacist or refer to the product package.
Cite this page
Page URL
HTML Link
APA Style Citation
- Bivatracin aerosol — Product — TabletWise.com. (n.d.). Retrieved April 23, 2023, from https://www.tabletwise.com/egypt/bivatracin-aerosol
MLA Style Citation
- «Bivatracin aerosol — Product — TabletWise.com» Tabletwise.com. N.p., n.d. Web. 23 Apr. 2023.
Chicago Style Citation
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Last updated date
This page was last updated on 9/27/2020.
This page provides information for Bivatracin aerosol Product in English.
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Bivatracin
Neomycin, Bacitracin
Topical Antibacterial Aerosol powder Spray
Composition :
Each 150 ml of Bivatracin aerosol powder contains:
Neomycin In the form of Neomycin Sulphate 165000 IU
Bacitracin in the form of Bacitracin Zinc 12500 lU
Aerosol Hydrocarbon to 15O ml
Action :
A wide range of antibacterial action is provided by the overlapping spectra of Neomycin and Badtracin. Bivatradn is used for topical treannent of most infections caused by gram-positive and gram-negative bacteria. it is practically not absorbed, therefore it has no systemic action.
Indications :
Dermatology:
– Pyodermia epidermal (impetigo group).
– Epidermocutaneous pyodermia (folliculitis}-primarily to prevent spread of infection.
– Superinfections of surface wounds and burns.
– Bacterial dermatopathies (ecthyma gangrenosum).
– Prevention of pyococcal supemtectrons In case of increased risk of their occurrence (herpes simplex, berpes roster, bites of insects).
Otology:
– Inflammation of the external ear canal.
– For proph)1axis, Bivatracin is also used in surgery and otorhinolaryngology.
Contra-indications :
– Hypersensitivity to Neomycin, Bacitracin and other ingredients of this combination.
– Perforation of the eardrum at local application into ear canal.
Warnings :
Systemic absorption can occur following application 0ver ,large areas (> 20%) un wounds burns or ulcerations Since systemic absorption can occur through the skin, Bivatracin should be used cautiously in patients with renal
insufficiency as rt may increase the hazard of nephrotoxicity and ototoxicity.
bivatracin should be discontinued If any signs of skin irritation or hypersensitivity occur.
Special warnings :
Pregnancy and lactation:
– Bivatradn should be used during pregnanc;y and lactation only If dearly Indicated and should not be used over wide areas and for prolonged periods to prevent the risk of systemic absorption associated with topical use. – Aerosol container is under pressure, it contains a gas propellant – D0 not perforate or bum, even when empty.
INFLAMMABLE :
– Bivatrecin should be kept out of reach of children.
– For external application only.
Drug Interactions :
None reported
Dosage and administration :
– Shake the aerosol container vigorously and spray the powder to the affected area once or several times daily from a distana> of 20 ID 25an.
– Do not iodine to an angle greater than 450•
– After use dean the valve by b.Jming the aerosol container
– Occasional agglomeration of powder In the valve can be deaned with a hypodermic needle no (1S-I7).
– Apply sparingly .
– Application of Bivatracln Spray should be limited to a maximum of one cans per day for not more than seven days.
– Apply the powder spray to the affected area as a thin layer once or several times daily.
Over dosage :
Systemic toxic effects (nephrotoxicity and ototoxicity) are unlikely to occur and may appear only after prolonged use of large doses CHer wkle areas of the affected skin.
Side effects :
Hypersensitivity reaction may occur, local skin irritation, swelling, itching, urticaria, contact dermatitis, super Infection have been reported.
Storage :
– Store Bivatracin Spray at a temperature below 25°C.
– Keep the mecHdne from freezing.
– Keep tne container away from dtrect heat sources.
– Keep out of reach of children.
Package :
Box containing a can spray of 150 mI aerosol powder and inner leaflet.
Produced by :
Manufactured By: ACDIMA International AIT